Currently the Company employs 37 people with an R&D laboratory facility in Leiden and a state-of-the-art ISO 9001 certified manufacturing plant in Naarden, the Netherlands. BAC BV was established in 1995 as a Unilever subsidiary and is collaborating with the leading life sciences vendors. They enable a reduced time to market, increased purity and yield and an overall lower cost of goods for biopharmaceutical drug development. Based on BAC's proprietary single-chain antibody technology called CaptureSelect, the products are suitable for the discovery, preclinical and clinical manufacturing of therapeutic proteins, including antibodies and antibody fragments. Capto Core 700 is also available as a bulk medium in a range of pack sizes from lab scale to production-scale.īAC discovers, develops and manufactures separation and affinity purification products for use across the value chain of biopharmaceutical R&D and manufacturing. The prepacked HiTrap™ and HiScreen™ formats simplify process development and scale-up. With Capto Core 700, flowthrough chromatography and a wide window of operation enable straightforward optimization. Smaller impurities bind to the internalized ligands, which are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The inactive outer layer excludes large molecules (Mr 700 000 and above) from entering the beads which can subsequently be collected in the column flowthrough. The Capto Core 700 medium employs core bead technology, with a ligand-activated core and inactive outer layer. Optimization and scale-up are both straightforward. Productivity is improved with up to 100-fold greater sample loadings and significantly higher flow rates. The medium is designed to be used in flowthrough mode for large targets (> M r 700 000) while scavenging smaller contaminants. Capto Core 700 offers a range of performance advantages over a typical gel filtration step. using Capto Core 700 Capto Core 700 is a chromatography medium (resin) optimized for purification of viruses and other large biomolecules. GE Healthcare's Capto Core 700 is a multimodal chromatography medium (resin) designed for intermediate purification and polishing of viruses and other large biomolecules.
High productivity alternative to group separation for intermediate purification and polishing, offering higher sample loads and flow rates than gel filtration
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